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有一类先天性或遗传性疾病，属于离子通道病，指的是某些负责编码细胞内钾、钠、钙等离子通道的基因发生突变，引起这些离子通道功能异常。因为心脏的每一次跳动都依赖于每一个细胞电活动的激活、传导与恢复，而这些电活动依赖于正常细胞内外离子的转运，因此这类遗传病往往都会引起心跳节律异常，并且常是恶性心律失常，导致心脏不能正常完成收缩与舒张活动，引起低血压、休克、心跳骤停等。
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